The levels of Serum Alkaline Phosphatase and Lactate Dehydrogenase in Hodgkin Lymphoma

Background: Hodgkin’s disease (HD) is a neoplastic disease originating in lymphoid tissue, which spreads to lymphoid structures and ultimately nonlymphoid tissues. Lactate Dehydrogenase and Alkaline Phosphatase are increased in blood following membrane cell damage. The aim of this study was to compare Lactate Dehydrogenase and Alkaline Phosphatase levels in children in different stages of Hodgkin’s Lymphoma with normal children. Materials and Methods: In the present study, the sera from 30 patients who suffered from Hodgkin’s Lymphoma and were referred to Children’s Medical Center, Tehran, Iran as well as 30 normal subjects were collected. The mean age was 7.5 years among patients and 6.8 years in normal subjects. Lactate Dehydrogenase and Alkaline Phosphatase levels were measured using kinetic and colorimetric methods. Data were analyzed using Pearson’s correlation coefficient and t- test. Results: Stages III and IV (advanced stages) were observed in 61.4% of the patients. Lactate Dehydrogenase level among patients was statistically higher in comparison with controls (P<0.01). There was also a statistically significant increase in Alkaline Phosphatase level among patients in comparison with controls (P<0.05). A comparison of both Lactate Dehydrogenase and Alkaline Phosphatase levels among patients with advanced stages (III , IV) and those with initial stages (I, II) , revealed elevated levels among patients in advanced stages (P<0.001). Conclusion: Lactate Dehydrogenase and Alkaline Phosphatase levels might be utilized as markers to determine Hodgkin’s lymphoma severity in addition to other markers. Key words: Lactate Dehydrogenase, Alkaline Phosphatase, Hodgkin’s disease.